Gastrointestinal Clinical Trials

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(Refer to Clinical Summary for age requirements)

Gastrointestinal

Protocol NRG GI008
Cancer Type: Colon Adjuvant
Fast Facts

COLON ADJUVANT CHEMOTHERAPY BASED ON EVALUATION OF RESIDUAL DISEASE (CIRCULATE-US)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S2001
Cancer Type: Metastatic Pancreatic
Fast Facts

Randomized Phase II Clinical Trial of Olaparib + Pembrolizumab vs. Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations.

Protocol Alliance A021806
Cancer Type: RESECTABLE PANCREATIC CANCER
Fast Facts

A PHASE III TRIAL OF PERIOPERATIVE VERSUS ADJUVANT CHEMOTHERAPY FOR RESECTABLE PANCREATIC CANCER

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S1922
Cancer Type: Small bowel Adenocarcinoma

Randomized Phase II Selection Study of Ramucirumab and Paclitaxel versus FOLFIRI in Refractory Small Bowel Adenocarcinoma

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA2176
Cancer Type: treatment-naïve metastatic anal cancer
Fast Facts

A Phase III Study of Immune checkpoint inhibition with chemotherapy in treatment-naïve metastatic anal cancer patients

Protocol EA2182
Cancer Type: Early Stage Anal Squamous Cell Carcinoma
Fast Facts

A Randomized Phase II Study of De-intensified Chemoradiation for Early Stage Anal Squamous Cell Carcinoma (DECREASE)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA2197
Cancer Type: Incidental Gallbladder Cancer
Fast Facts

Optimal Perioperative Therapy for Incidental Gallbladder Cancer (OPT-IN)- A Randomized Phase II/III Trial

Protocol EAY191 - A6
Cancer Type: Rare Cancer

A COMBOMATCH TREATMENT TRIAL: FOLFOX IN COMBINATION WITH BINIMETINIB AS 2ND LINE THERAPY FOR PATIENTS WITH ADVANCED BILIARY TRACT CANCERS WITH MAPK PATHWAY ALTERATIONS

Please check out the rare protocol list to locate other studies within this disease site.

Protocol NRG GI004
Cancer Type: Colorectal Cancer
Fast Facts

Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy with or without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients with Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal Cancer

Protocol SWOG S2107
Cancer Type: Metastatic Colorectal
Fast Facts

Randomized Phase II trial of encorafenib and cetuximab with or without nivolumab (NSC #748726) for patients with previously treated, microsatellite stable, BRAFV600E metastatic and/or unresectable colorectal cancer

Protocol EA2222
Cancer Type: Colorectal
Fast Facts

A Randomized Phase III Study of Systemic Therapy With or Without Hepatic Arterial Infusion for Unresectable Colorectal Liver Metastases: The PUMP Trial.

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA2212
Cancer Type: Gastric and GEJ
Fast Facts

 EA2212, “A Randomized Phase II Study of Perioperative Atezolizumab  +/- Chemotherapy in Resectable MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer”

Please check out the rare protocol list to locate other studies within this disease site.

Protocol PDM 9846
Cancer Type: Tissue Procurement
Fast Facts

Patient-Derived Models Tissue Procurement Protocol for the National Cancer Institute (NCI)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol WF 1806
Cancer Type: Cancer Control
Fast Facts

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults with Colorectal Cancer: The M&M Study

Protocol Alliance A221805
Cancer Type: CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY
Fast Facts

DULOXETINE TO PREVENT OXALIPLATIN-INDUCED CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE II TO PHASE III STUDY

Please check out the rare protocol list to locate other studies within this disease site.

Please check out the rare protocol list to locate other studies within this disease site.

Please check out the rare protocol list to locate other studies within this disease site.

Cancer clinical trials are research studies for developing better ways of detecting, treating, and eventually preventing cancer. By taking part in a clinical trial, you are among the first to receive new research treatments before they are widely available. Your participation in a clinical trial will influence the future direction of cancer care.

If you are interested in participating in a clinical trial, consult with your physician. Please note: clinical trials are not risk free. Patients must explore the options that are best for their individuals needs with the help of their physician.