Breast Clinical Trials

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(Refer to Clinical Summary for age requirements)

Breast

Protocol SWOG S2212
Cancer Type: Breast
Fast Facts

SHORTER ANTHRACYCLINE-FREE CHEMO IMMUNOTHERAPY ADAPTED TO PATHOLOGICAL RESPONSE IN EARLY TRIPLE NEGATIVE BREAST CANCER (SCARLET), A RANDOMIZED PHASE III STUDY

Please check out the rare protocol list to locate other studies within this disease site.

Protocol Alliance A011801
Cancer Type: HER2 positive Breast Cancer
Fast Facts

The COMPASSHER2 Trials (COMprehensive Use of Pathologic Response ASSessment to Optimize Therapy in HER2-Positive Breast Cancer): COMPASSHER2 Residual Disease (RD), A Double-Blinded, Phase III Randomized Trial of T-DM1 and Placebo Compared with T-DM1 and Tucatinib

Protocol Alliance A012103
Cancer Type: Breast- Post-Neoadjuvant
Fast Facts

OPTIMICE-PCR: DE-ESCALATION OF THERAPY IN EARLY-STAGE TNBC PATIENTS WHO ACHIEVE PCR AFTER NEOADJUVANT CHEMOTHERAPY WITH CHECKPOINT INHIBITOR THERAPY

Please check out the rare protocol list to locate other studies within this disease site.

Protocol CCTG MA.39 Adjuvant
Cancer Type: LOW RISK NODE POSITIVE BREAST CANCER
Fast Facts

TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer

Protocol NRG BR007
Cancer Type: Stage 1, Hormone Sensitive Her2 negative
Fast Facts

Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage 1, Hormone Sensitive HER2-Negative, Oncotype Recurrence Score < 18 Breast Cancer (DEBRA) De-Escalation of Breast Radiation

Protocol NRG BR009
Cancer Type: Breast
Fast Facts

Protocol NRG-BR009, A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET) (NCT05879926)

Protocol NRG BR008
Cancer Type: Breast
Fast Facts

NRG-BR008, "A Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer” (HERO)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S2007
Cancer Type: HER2-Negative Breast Cancer
Fast Facts

 A Phase II Trial of Sacituzumab Govitecan for Patients with HER2-Negative Breast Cancer and Brain Metastases

Protocol EAY191 - N2
Cancer Type: Rare Cancer
Fast Facts

PHASE 2 TRIAL OF FULVESTRANT AND BINIMETINIB IN PATIENTS WITH HORMONE RECEPTOR-POSITIVE METASTATIC BREAST CANCER WITH A FRAMESHIFT OR NONSENSE MUTATION OR GENOMIC DELETION IN NF1

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S2010
Cancer Type: Breast
Fast Facts

A Randomized Phase III Trial Comparing Active Symptom Monitoring Plus Patient Education Versus Patient Education Alone To Improve Persistence With Endocrine Therapy In Young Women With Stage I-III Breast Cancer (Aspen)

Protocol WF 2202
Cancer Type: Breast
Fast Facts

WF-2202, Optimizing Psychosocial Intervention for Breast Cancer-related Sexual Morbidity: The Sexual Health and Intimacy Education (SHINE) Trial

Protocol EAQ221CD
Cancer Type: Breast
Fast Facts

EAQ221CD: Improving Medication Adherence in Metastatic Breast Cancer using a CONnected CUstomized Treatment Platform (CONCURxP)

Protocol SWOG S1703
Cancer Type: METASTATIC BREAST CANCER
Fast Facts

Randomized Non-Inferiority Trial Comparing Overall Survival of Patients Monitored With Serum Tumor Marker Directed Disease Monitoring (STMDDM) Versus Usual Care in Patients With Metastatic Hormone Receptor Positive HER-2 Negative Breast Cancer

Protocol Alliance A191901
Cancer Type: Cancer Control
Fast Facts

Optimizing Endocrine Therapy Through Motivational Interviewing and Text Interventions

Protocol Alliance A211801
Cancer Type: BRCA Breast
Fast Facts

A211801 - BRCA-P: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, International Phase 3 Study to determine the Preventive Effect of Denosumab on Breast Cancer in Women carrying a BRCA1 Germline Mutation

Protocol PDM 9846
Cancer Type: Tissue Procurement
Fast Facts

Patient-Derived Models Tissue Procurement Protocol for the National Cancer Institute (NCI)

Protocol NRG CC011
Cancer Type: Breast
Fast Facts

 

NRG CC011-Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors: A Multi-Center Randomized Double-Blinded Controlled Trial

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA1151 (TMIST)
Cancer Type: Screening
Fast Facts

Tomosynthesis Mammographic Imaging Screening Trial (TMIST)

Please check out the rare protocol list to locate other studies within this disease site.

Cancer clinical trials are research studies for developing better ways of detecting, treating, and eventually preventing cancer. By taking part in a clinical trial, you are among the first to receive new research treatments before they are widely available. Your participation in a clinical trial will influence the future direction of cancer care.

If you are interested in participating in a clinical trial, consult with your physician. Please note: clinical trials are not risk free. Patients must explore the options that are best for their individuals needs with the help of their physician.