Adult Clinical Trials

Brain/CNS

Protocol NRG BN011
Cancer Type: Methylated MGMT Promoter Glioblastoma
Fast Facts

A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients with Methylated MGMT Promoter Glioblastoma

Please check out the rare protocol list to locate other studies within this disease site.

Protocol Alliance A071401
Cancer Type: MENINGIOMAS WITH SMO/AKT/NF2 MUTATIONS
Fast Facts

PHASE II TRIAL OF SMO/AKT/NF2/CDK INHIBITORS IN PROGRESSIVE MENINGIOMAS WITH SMO/AKT/NF2/CDK PATHWAY MUTATIONS

Protocol NRG BN003
Cancer Type: MENINGIOMA
Fast Facts

Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma

Please check out the rare protocol list to locate other studies within this disease site.

Protocol Alliance A071701
Cancer Type: Brain metastases
Fast Facts

Genomically-Guided Treatment Trial in Brain Metastases

Please check out the rare protocol list to locate other studies within this disease site.

Breast

Protocol SWOG S2212
Cancer Type: Breast
Fast Facts

SHORTER ANTHRACYCLINE-FREE CHEMO IMMUNOTHERAPY ADAPTED TO PATHOLOGICAL RESPONSE IN EARLY TRIPLE NEGATIVE BREAST CANCER (SCARLET), A RANDOMIZED PHASE III STUDY

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S1706
Cancer Type: Inflammatory Breast Cancer
Fast Facts

A Phase II Randomized Trial of Olaparib (NSC-747856) Administered Concurrently with Radiotherapy versus Radiotherapy Alone for Inflammatory Breast Cancer

Protocol Alliance A011801
Cancer Type: HER2 positive Breast Cancer
Fast Facts

The COMPASSHER2 Trials (COMprehensive Use of Pathologic Response ASSessment to Optimize Therapy in HER2-Positive Breast Cancer): COMPASSHER2 Residual Disease (RD), A Double-Blinded, Phase III Randomized Trial of T-DM1 and Placebo Compared with T-DM1 and Tucatinib

Protocol Alliance A012103
Cancer Type: Breast- Post-Neoadjuvant
Fast Facts

OPTIMICE-PCR: DE-ESCALATION OF THERAPY IN EARLY-STAGE TNBC PATIENTS WHO ACHIEVE PCR AFTER NEOADJUVANT CHEMOTHERAPY WITH CHECKPOINT INHIBITOR THERAPY

Please check out the rare protocol list to locate other studies within this disease site.

Protocol CCTG MA.39 Adjuvant
Cancer Type: LOW RISK NODE POSITIVE BREAST CANCER
Fast Facts

TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer

Protocol NRG BR007
Cancer Type: Stage 1, Hormone Sensitive Her2 negative
Fast Facts

Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage 1, Hormone Sensitive HER2-Negative, Oncotype Recurrence Score < 18 Breast Cancer (DEBRA) De-Escalation of Breast Radiation

Protocol NRG BR009
Cancer Type: Breast
Fast Facts

Protocol NRG-BR009, A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET) (NCT05879926)

Protocol NRG BR008
Cancer Type: Breast
Fast Facts

NRG-BR008, "A Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer” (HERO)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S2007
Cancer Type: HER2-Negative Breast Cancer
Fast Facts

 A Phase II Trial of Sacituzumab Govitecan for Patients with HER2-Negative Breast Cancer and Brain Metastases

Protocol EAY191 - N2
Cancer Type: Rare Cancer
Fast Facts

PHASE 2 TRIAL OF FULVESTRANT AND BINIMETINIB IN PATIENTS WITH HORMONE RECEPTOR-POSITIVE METASTATIC BREAST CANCER WITH A FRAMESHIFT OR NONSENSE MUTATION OR GENOMIC DELETION IN NF1

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S2010
Cancer Type: Breast
Fast Facts

A Randomized Phase III Trial Comparing Active Symptom Monitoring Plus Patient Education Versus Patient Education Alone To Improve Persistence With Endocrine Therapy In Young Women With Stage I-III Breast Cancer (Aspen)

Protocol WF 2202
Cancer Type: Breast
Fast Facts

WF-2202, Optimizing Psychosocial Intervention for Breast Cancer-related Sexual Morbidity: The Sexual Health and Intimacy Education (SHINE) Trial

Protocol EAQ221CD
Cancer Type: Breast
Fast Facts

EAQ221CD: Improving Medication Adherence in Metastatic Breast Cancer using a CONnected CUstomized Treatment Platform (CONCURxP)

Protocol SWOG S1703
Cancer Type: METASTATIC BREAST CANCER
Fast Facts

Randomized Non-Inferiority Trial Comparing Overall Survival of Patients Monitored With Serum Tumor Marker Directed Disease Monitoring (STMDDM) Versus Usual Care in Patients With Metastatic Hormone Receptor Positive HER-2 Negative Breast Cancer

Protocol Alliance A191901
Cancer Type: Cancer Control
Fast Facts

Optimizing Endocrine Therapy Through Motivational Interviewing and Text Interventions

Protocol Alliance A211801
Cancer Type: BRCA Breast
Fast Facts

A211801 - BRCA-P: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, International Phase 3 Study to determine the Preventive Effect of Denosumab on Breast Cancer in Women carrying a BRCA1 Germline Mutation

Protocol PDM 9846
Cancer Type: Tissue Procurement
Fast Facts

Patient-Derived Models Tissue Procurement Protocol for the National Cancer Institute (NCI)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA1151 (TMIST)
Cancer Type: Screening
Fast Facts

Tomosynthesis Mammographic Imaging Screening Trial (TMIST)

Please check out the rare protocol list to locate other studies within this disease site.

Cancer Care Delivery (CCDR)

Protocol EAQ221CD
Cancer Type: Breast
Fast Facts

EAQ221CD: Improving Medication Adherence in Metastatic Breast Cancer using a CONnected CUstomized Treatment Platform (CONCURxP)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EAQ222CD
Cancer Type: CCDR - multsite
Fast Facts

EAQ222CD: “Effectiveness of Out-of-Pocket Cost COMmunication and Financial Navigation (CostCOM) in Cancer Patients”

Protocol SWOG S1912CD
Cancer Type: CCDR
Fast Facts

A RANDOMIZED TRIAL ADDRESSING CANCER-RELATED FINANCIAL HARDSHIP THROUGH
DELIVERY OF A PROACTIVE FINANCIAL NAVIGATION INTERVENTION (CREDIT)

Please check out the rare protocol list to locate other studies within this disease site.

Cancer Control

Protocol Alliance A212102
Cancer Type: Early Detection Blood Tests
Fast Facts

Blinded Reference Set for Multicancer Early Detection Blood Tests

Protocol PDM 9846
Cancer Type: Tissue Procurement
Fast Facts

Patient-Derived Models Tissue Procurement Protocol for the National Cancer Institute (NCI)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S1703
Cancer Type: METASTATIC BREAST CANCER
Fast Facts

Randomized Non-Inferiority Trial Comparing Overall Survival of Patients Monitored With Serum Tumor Marker Directed Disease Monitoring (STMDDM) Versus Usual Care in Patients With Metastatic Hormone Receptor Positive HER-2 Negative Breast Cancer

Protocol Alliance A191901
Cancer Type: Cancer Control
Fast Facts

Optimizing Endocrine Therapy Through Motivational Interviewing and Text Interventions

Protocol WF 2202
Cancer Type: Breast
Fast Facts

WF-2202, Optimizing Psychosocial Intervention for Breast Cancer-related Sexual Morbidity: The Sexual Health and Intimacy Education (SHINE) Trial

Please check out the rare protocol list to locate other studies within this disease site.

Protocol WF 1806
Cancer Type: Cancer Control
Fast Facts

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults with Colorectal Cancer: The M&M Study

Please check out the rare protocol list to locate other studies within this disease site.

Protocol Alliance A211901
Cancer Type: Rural Cancer Survivors
Fast Facts

REACHING RURAL CANCER SURVIVORS WHO SMOKE USING TEXT-BASED CESSATION INTERVENTIONS

Protocol URCC 21038
Cancer Type: Cancer Survivors
Fast Facts

Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 Immunotherapy in a Community Oncology Setting

Protocol SWOG S2205
Cancer Type: peripheral neuropathy
Fast Facts

S2205, ICE COMPRESS: RANDOMIZED TRIAL OF LIMB CRYOCOMPRESSION VERSUS CONTINUOUS COMPRESSION VERSUS LOW CYCLIC COMPRESSION FOR THE PREVENTION OF TAXANE-INDUCED PERIPHERAL NEUROPATHY
 

Protocol URCC 22063 (LOTUS)
Cancer Type: Observational
Fast Facts

Longitudinal Observational Trial to Uncover Subtypes of Cancer Cachexia

Protocol URCC 18007
Cancer Type: Cancer-Related Fatigue
Fast Facts

Randomized Placebo-Controlled Trial of Bupropion for Cancer-Related Fatigue

Protocol URCC 19075
Cancer Type: multi-site
Fast Facts

URCC-19075 “Multi-Center Randomized Controlled Phase II Trial of Exercise to Treat Chemotherapy-Induced Peripheral Neuropathy (CIPN)”

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA1151 (TMIST)
Cancer Type: Screening
Fast Facts

Tomosynthesis Mammographic Imaging Screening Trial (TMIST)

Protocol DCP-001
Cancer Type: Multisite - Screening

Use of a Clinical Trial Screening Tool to Address Cancer Health Disparities in the NCI Community Oncology Research Program (NCORP)

Protocol NRG CC005 FORTE
Cancer Type: Colonoscopy
Fast Facts

FORTE (Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps)

Please check out the rare protocol list to locate other studies within this disease site.

Endocrine/Neuroendocrine

Protocol SWOG S2012
Cancer Type: RARE

RANDOMIZED PHASE II/III TRIAL OF FIRST LINE PLATINUM/ETOPOSIDE WITH OR WITHOUT
ATEZOLIZUMAB (NSC#783608) IN PATIENTS WITH POORLY DIFFERENTIATED
EXTRAPULMONARY SMALL CELL NEUROENDOCRINE CARCINOMAS (NEC)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol Alliance A021804
Cancer Type: ADVANCED PHEOCHROMOCYTOMA AND PARAGANGLIOMA

A PROSPECTIVE, MULTI-INSTITUTIONAL PHASE II TRIAL EVALUATING TEMOZOLOMIDE VS. TEMOZOLOMIDE AND OLAPARIB FOR ADVANCED PHEOCHROMOCYTOMA AND PARAGANGLIOMA

Please check out the rare protocol list to locate other studies within this disease site.

Gastrointestinal

Protocol NRG GI008
Cancer Type: Colon Adjuvant
Fast Facts

COLON ADJUVANT CHEMOTHERAPY BASED ON EVALUATION OF RESIDUAL DISEASE (CIRCULATE-US)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S2001
Cancer Type: Metastatic Pancreatic
Fast Facts

Randomized Phase II Clinical Trial of Olaparib + Pembrolizumab vs. Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations.

Protocol Alliance A021806
Cancer Type: RESECTABLE PANCREATIC CANCER
Fast Facts

A PHASE III TRIAL OF PERIOPERATIVE VERSUS ADJUVANT CHEMOTHERAPY FOR RESECTABLE PANCREATIC CANCER

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S1922
Cancer Type: Small bowel Adenocarcinoma

Randomized Phase II Selection Study of Ramucirumab and Paclitaxel versus FOLFIRI in Refractory Small Bowel Adenocarcinoma

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA2176
Cancer Type: treatment-naïve metastatic anal cancer
Fast Facts

A Phase III Study of Immune checkpoint inhibition with chemotherapy in treatment-naïve metastatic anal cancer patients

Protocol EA2182
Cancer Type: Early Stage Anal Squamous Cell Carcinoma
Fast Facts

A Randomized Phase II Study of De-intensified Chemoradiation for Early Stage Anal Squamous Cell Carcinoma (DECREASE)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA2197
Cancer Type: Incidental Gallbladder Cancer
Fast Facts

Optimal Perioperative Therapy for Incidental Gallbladder Cancer (OPT-IN)- A Randomized Phase II/III Trial

Protocol EAY191 - A6
Cancer Type: Rare Cancer

A COMBOMATCH TREATMENT TRIAL: FOLFOX IN COMBINATION WITH BINIMETINIB AS 2ND LINE THERAPY FOR PATIENTS WITH ADVANCED BILIARY TRACT CANCERS WITH MAPK PATHWAY ALTERATIONS

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA2222
Cancer Type: Colorectal
Fast Facts

A Randomized Phase III Study of Systemic Therapy With or Without Hepatic Arterial Infusion for Unresectable Colorectal Liver Metastases: The PUMP Trial.

Protocol SWOG S2107
Cancer Type: Metastatic Colorectal
Fast Facts

Randomized Phase II trial of encorafenib and cetuximab with or without nivolumab (NSC #748726) for patients with previously treated, microsatellite stable, BRAFV600E metastatic and/or unresectable colorectal cancer

Protocol NRG GI004
Cancer Type: Colorectal Cancer
Fast Facts

Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy with or without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients with Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal Cancer

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EA2212
Cancer Type: Gastric and GEJ
Fast Facts

 EA2212, “A Randomized Phase II Study of Perioperative Atezolizumab  +/- Chemotherapy in Resectable MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer”

Please check out the rare protocol list to locate other studies within this disease site.

Protocol PDM 9846
Cancer Type: Tissue Procurement
Fast Facts

Patient-Derived Models Tissue Procurement Protocol for the National Cancer Institute (NCI)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol WF 1806
Cancer Type: Cancer Control
Fast Facts

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults with Colorectal Cancer: The M&M Study

Please check out the rare protocol list to locate other studies within this disease site.

Please check out the rare protocol list to locate other studies within this disease site.

Genitourinary

Protocol SWOG S1802
Cancer Type: Metastatic Prostate Cancer
Fast Facts

Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer

Protocol EA8171
Cancer Type: Prostate Cancer
Fast Facts

Multiparametric MRI (mpMRI) for Preoperative Staging and Treatment Planning for Newly-Diagnosed Prostate Cancer

Protocol NRG GU009
Cancer Type: HIGH RISK PROSTATE CANCER
Fast Facts

PARALLEL PHASE III RANDOMIZED TRIALS FOR HIGH RISK PROSTATE CANCER EVALUATING DE-INTENSIFICATION FOR LOWER GENOMIC RISK AND INTENSIFICATION OF CONCURRENT THERAPY FOR HIGHER GENOMIC RISK WITH RADIATION (PREDICT-RT*)

Protocol NRG GU010
Cancer Type: Prostate Cancer
Fast Facts

NRG-GU010 - Parallel Phase III Randomized Trials of Genomic Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (GUIDANCE)

Protocol NRG GU011
Cancer Type: Prostate
Fast Facts

NRG-GU011, A Phase II Double-Blinded, Placebo Controlled Trial of Prostate Oligometastatic Radiotherapy with or without Androgen Deprivation Therapy in Oligometastatic Prostate Cancer (NRG PROMETHEAN)

Protocol NRG GU013
Cancer Type: Prostate
Fast Facts

NRG-GU013, The Phase III ‘High Five Trial’ Five Fraction Radiation For High-Risk Prostate Cancer

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S2200
Cancer Type: Renal Cell
Fast Facts

SWOG - S2200, “A Phase II Randomized Trial of Cabozantinib (NSC #761968) with or without Atezolizumab (NSC #783608) in Patients with Advanced Papillary Renal Cell Carcinoma (PAPMET2).”

Protocol SWOG S1931
Cancer Type: METASTATIC RENAL CELL CARCINOMA
Fast Facts

PHASE III TRIAL OF IMMUNOTHERAPY-BASED DRUG COMBINATION THERAPY WITH OR WITHOUT CYTOREDUCTIVE NEPHRECTOMY FOR METASTATIC RENAL CELL CARCINOMA (PROBE TRIAL)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol Alliance A031803
Cancer Type: BCG-Unresponsive Non Muscle Invasive Bladder
Fast Facts

Phase II Trial of Intravesical Gemcitabine and MK-3475 (Pembrolizumab) in the Treatment Patients with BCG-Unresponsive Non-Muscle Invasive Bladder Cancer

Protocol SWOG S1937
Cancer Type: Metastatic Urothelial Carcinoma
Fast Facts

A Phase III Randomized Trial of Eribulin (NSC #707389) with Gemcitabine versus Standard of Care (Physician’s Choice) for Treatment of Metastatic Urothelial Carcinoma Refractory to, or Ineligible for, Anti PD1/PDL1 Therapy

Please check out the rare protocol list to locate other studies within this disease site.

Please check out the rare protocol list to locate other studies within this disease site.

Gynecologic

Protocol NRG CC008
Cancer Type: Ovarian Cancer Among BRCA1 Carriers
Fast Facts

A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers [SOROCk] 

Protocol NRG GY019
Cancer Type: Carcinoma of the Ovary or Peritoneum
Fast Facts

A Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum

Protocol EAY191 - N4
Cancer Type: Rare Cancer

A RANDOMIZED TRIAL OF SELUMETINIB AND OLAPARIB
OR SELUMETINIB ALONE IN PATIENTS WITH RECURRENT OR
PERSISTENT RAS PATHWAY MUTANT OVARIAN AND ENDOMETRIAL
CANCERS

Please check out the rare protocol list to locate other studies within this disease site.

Protocol NRG GY026
Cancer Type: Endometrial serous carcinoma or carcinosarcoma
Fast Facts

A Phase II/III study of paclitaxel/carboplatin alone or combined with either trastuzumab and hyaluronidase-oysk (HERCEPTIN HYLECTA) or pertuzumab trastuzumab and hyaluronidase-zzfx (PHESGO) in HER2 positive, stage I-IV endometrial serous carcinoma or carcinosarcoma

Please check out the rare protocol list to locate other studies within this disease site.

Protocol NRG GY024
Cancer Type: Vulvar Cancer
Fast Facts

Groningen International Study on Sentinel Nodes in Vulvar Cancer III (GROINSS-V III), a prospective phase II treatment trial

Please check out the rare protocol list to locate other studies within this disease site.

Head and Neck

Protocol EA3161
Cancer Type: HPV Positive OPCA
Fast Facts

A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPCA

Protocol RTOG 1216
Cancer Type: Pathologic High-Risk Squamous Cell Cancer
Fast Facts

Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

Please check out the rare protocol list to locate other studies within this disease site.

Protocol NRG HN010
Cancer Type: RARE

A CONTROLLED, RANDOMIZED PHASE II TRIAL OF DOCETAXEL PLUS TRASTUZUMAB VERSUS ADO-TRASTUZUMAB EMTANSINE FOR RECURRENT, METASTATIC, OR TREATMENT-NAÏVE, UNRESECTABLE HER2-POSITIVE SALIVARY GLAND CANCER

Please check out the rare protocol list to locate other studies within this disease site.

Leukemia

Protocol Alliance A041501
Cancer Type: NEWLY DIAGNOSED PRECURSOR B-CELL ALL
Fast Facts

A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (a Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) With Newly Diagnosed Precursor B-Cell ALL

Please check out the rare protocol list to locate other studies within this disease site.

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S1925
Cancer Type: CLL/SLL
Fast Facts

RANDOMIZED, PHASE III STUDY OF EARLY INTERVENTION WITH VENETOCLAX AND OBINUTUZUMAB VERSUS DELAYED THERAPY WITH VENETOCLAX AND OBINUTUZUMAB IN NEWLY DIAGNOSED ASYMPTOMATIC HIGH-RISK PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL): EVOLVE CLL/SLL STUDY

Please check out the rare protocol list to locate other studies within this disease site.

Protocol NHLBI-MDS
Cancer Type: Myelodysplastic Syndromes
Fast Facts

The National Myelodysplastic Syndromes (MDS) Study

Please check out the rare protocol list to locate other studies within this disease site.

Lung

Protocol Alliance A081801
Cancer Type: resected NSCLC
Fast Facts

Integration of immunotherapy into adjuvant therapy for resected NSCLC: ALCHEMIST chemo-IO

Protocol EA5162
Cancer Type: Advanced NSCLC
Fast Facts

Phase II Study of AZD9291 (Osimertinib) in Advanced NSCLC Patients with Exon 20 Insertion Mutations in EGFR

Protocol SWOG S1914
Cancer Type: Early Stage NSCLC
Fast Facts

A Randomized Phase III Trial of Induction/Consolidation Atezolizumab (NSC #783608) + SBRT Versus SBRT Alone in High Risk, Early Stage NSCLC

Protocol SWOG S1900E
Cancer Type: NS NSCLC
Fast Facts

A Phase II Study of Sotorasib (AMG 510) in Participants with Previously Treated Stage IV or Recurrent KRAS G12C Mutated Non-Squamous Non-Small Cell Lung Cancer (ECOG-ACRIN Lung-MAP Sub-Study)

Protocol SWOG S2302
Cancer Type: Lung
Fast Facts

Non-Chemotherapy Treatment (ramucirumab plus pembrolizumab) or Usual Care forAdvanced Non-Small Cell Lung Cancer Following Immunotherapy

Protocol Alliance A082002
Cancer Type: Non-Small Cell Lung Cancer
Fast Facts

A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy with or Without SBRT for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S1827
Cancer Type: Small Cell Lung
Fast Facts

MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI):  A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)

Protocol NRG LU007
Cancer Type: ES-SCLC
Fast Facts

 RAndomized Phase II/III Trial Of Consolidation Radiation + Immuno-therapy for ES-SCLC:  RAPTOR trial

Please check out the rare protocol list to locate other studies within this disease site.

Protocol Alliance A092001
Cancer Type: RARE

PHASE 2 RANDOMIZED TRIAL OF NEOADJUVANT OR PALLIATIVE CHEMOTHERAPY WITH OR WITHOUT IMMUNOTHERAPY FOR PERITONEAL MESOTHELIOMA

Please check out the rare protocol list to locate other studies within this disease site.

Protocol PDM 9846
Cancer Type: Tissue Procurement
Fast Facts

Patient-Derived Models Tissue Procurement Protocol for the National Cancer Institute (NCI)

Please check out the rare protocol list to locate other studies within this disease site.

Protocol Alliance A151216
Cancer Type: Non-Small Cell Lung
Fast Facts

Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

Sub-Studies to ALCHEMIST: E4512 and EA5142

Protocol LUNG MAP
Cancer Type: NSCLC
Fast Facts

A Master Protocol to Evaluate Biomarker-Driven Therapies and Immunotherapies in Previously-Treated Non-Small Cell Lung Cancer (Lung-MAP Screening Study)

Please check out the rare protocol list to locate other studies within this disease site.

Lymphoma

Protocol SWOG S2114
Cancer Type: Lymphoma
Fast Facts

 A Randomized Phase II trial of Consolidation Therapy following CD19 CAR T-cell Treatment for Relapsed/Refractory Large B-cell Lymphoma or Grade IIIB Follicular Lymphoma

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S1608
Cancer Type: FOLLICULAR LYMPHOMA
Fast Facts

Randomized Phase II Trial in Early Relapsing or Refractory Follicular Lymphoma

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S1925
Cancer Type: CLL/SLL
Fast Facts

RANDOMIZED, PHASE III STUDY OF EARLY INTERVENTION WITH VENETOCLAX AND OBINUTUZUMAB VERSUS DELAYED THERAPY WITH VENETOCLAX AND OBINUTUZUMAB IN NEWLY DIAGNOSED ASYMPTOMATIC HIGH-RISK PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL): EVOLVE CLL/SLL STUDY

Please check out the rare protocol list to locate other studies within this disease site.

Protocol COG AHOD2131
Cancer Type: Classic Hodgkin Lymphoma
Fast Facts

COG-AHOD2131: A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy with Immuno-oncology Therapy for Children and Adults with Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma

Patients must be 5 to 60 years of age at the time of enrollment.

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EAQ211
Cancer Type: Lymphoma
Fast Facts

EAQ211: Social genomic mechanisms of health disparities among Adolescent and Young Adult (AYA) cancer survivors

Please check out the rare protocol list to locate other studies within this disease site.

Multisite

Protocol URCC 19075
Cancer Type: multi-site
Fast Facts

URCC-19075 “Multi-Center Randomized Controlled Phase II Trial of Exercise to Treat Chemotherapy-Induced Peripheral Neuropathy (CIPN)”

Protocol URCC 18007
Cancer Type: Cancer-Related Fatigue
Fast Facts

Randomized Placebo-Controlled Trial of Bupropion for Cancer-Related Fatigue

Please check out the rare protocol list to locate other studies within this disease site.

Protocol TAPUR
Cancer Type: Multisite
Fast Facts

Targeted Agent and Profiling Utilization Registry (TAPUR) Study

Protocol Alliance A071701
Cancer Type: Brain metastases
Fast Facts

Genomically-Guided Treatment Trial in Brain Metastases

Protocol Alliance EAY 191-A3
Cancer Type: Rare Cancer
Fast Facts

A ComboMATCH Treatment Trial: Palbociclib and Binimetinib in RAS-Mutant Cancers

Protocol EAY191 - S3
Cancer Type: Rare Cancer

Phase 2 Study of Paclitaxel + Ipatasertib in Taxane-Refractory
Participants with AKT-Altered Advanced Non-Breast Solid Tumors

Protocol EAY191 - A3
Cancer Type: Rare Cancer
Fast Facts

A COMBOMATCH TREATMENT TRIAL: PALBOCICLIB AND BINIMETINIB IN RAS-MUTANT CANCERS

Please check out the rare protocol list to locate other studies within this disease site.

Protocol 10323 Moonshot
Cancer Type: Biospecimen
Fast Facts

Cancer Moonshot Biobank Research Protocol

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EAQ222CD
Cancer Type: CCDR - multsite
Fast Facts

EAQ222CD: “Effectiveness of Out-of-Pocket Cost COMmunication and Financial Navigation (CostCOM) in Cancer Patients”

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EAY191
Cancer Type: Multisite
Fast Facts

Molecular Analysis for Combination Therapy Choice (ComboMATCH)

Protocol DCP-001
Cancer Type: Multisite - Screening

Use of a Clinical Trial Screening Tool to Address Cancer Health Disparities in the NCI Community Oncology Research Program (NCORP)

Please check out the rare protocol list to locate other studies within this disease site.

Myeloma

Protocol EAA181
Cancer Type: Newly diagnosed Multiple Myeloma
Fast Facts

Effective Quadruplet Utilization After Treatment Evaluation (EQUATE): A Randomized Phase 3 Trial for Newly Diagnosed Multiple Myeloma Not Intended for Early Autologous Transplantation

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S2209
Cancer Type: Mulitple Myloma
Fast Facts

S2209 A Phase III Randomized Trial for Newly Diagnosed Multiple Myeloma (NDMM) Patients Considered Frail or in a Subset of “Intermediate Fit” Comparing Upfront Three-drug Induction Regimens Followed by Double- or Single-Agent Maintenance

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EAA173
Cancer Type: Smoldering Myeloma
Fast Facts

Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)

Please check out the rare protocol list to locate other studies within this disease site.

Please check out the rare protocol list to locate other studies within this disease site.

Rare

Protocol EAY191 - N2
Cancer Type: Rare Cancer
Fast Facts

PHASE 2 TRIAL OF FULVESTRANT AND BINIMETINIB IN PATIENTS WITH HORMONE RECEPTOR-POSITIVE METASTATIC BREAST CANCER WITH A FRAMESHIFT OR NONSENSE MUTATION OR GENOMIC DELETION IN NF1

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S2012
Cancer Type: RARE

RANDOMIZED PHASE II/III TRIAL OF FIRST LINE PLATINUM/ETOPOSIDE WITH OR WITHOUT
ATEZOLIZUMAB (NSC#783608) IN PATIENTS WITH POORLY DIFFERENTIATED
EXTRAPULMONARY SMALL CELL NEUROENDOCRINE CARCINOMAS (NEC)

Protocol Alliance A021804
Cancer Type: ADVANCED PHEOCHROMOCYTOMA AND PARAGANGLIOMA

A PROSPECTIVE, MULTI-INSTITUTIONAL PHASE II TRIAL EVALUATING TEMOZOLOMIDE VS. TEMOZOLOMIDE AND OLAPARIB FOR ADVANCED PHEOCHROMOCYTOMA AND PARAGANGLIOMA

Please check out the rare protocol list to locate other studies within this disease site.

Protocol SWOG S1922
Cancer Type: Small bowel Adenocarcinoma

Randomized Phase II Selection Study of Ramucirumab and Paclitaxel versus FOLFIRI in Refractory Small Bowel Adenocarcinoma

Protocol EAY191 - A6
Cancer Type: Rare Cancer

A COMBOMATCH TREATMENT TRIAL: FOLFOX IN COMBINATION WITH BINIMETINIB AS 2ND LINE THERAPY FOR PATIENTS WITH ADVANCED BILIARY TRACT CANCERS WITH MAPK PATHWAY ALTERATIONS

Please check out the rare protocol list to locate other studies within this disease site.

Please check out the rare protocol list to locate other studies within this disease site.

Protocol NRG HN010
Cancer Type: RARE

A CONTROLLED, RANDOMIZED PHASE II TRIAL OF DOCETAXEL PLUS TRASTUZUMAB VERSUS ADO-TRASTUZUMAB EMTANSINE FOR RECURRENT, METASTATIC, OR TREATMENT-NAÏVE, UNRESECTABLE HER2-POSITIVE SALIVARY GLAND CANCER

Please check out the rare protocol list to locate other studies within this disease site.

Protocol Alliance A092001
Cancer Type: RARE

PHASE 2 RANDOMIZED TRIAL OF NEOADJUVANT OR PALLIATIVE CHEMOTHERAPY WITH OR WITHOUT IMMUNOTHERAPY FOR PERITONEAL MESOTHELIOMA

Please check out the rare protocol list to locate other studies within this disease site.

Protocol EAY191 - A3
Cancer Type: Rare Cancer
Fast Facts

A COMBOMATCH TREATMENT TRIAL: PALBOCICLIB AND BINIMETINIB IN RAS-MUTANT CANCERS

Protocol EAY191 - N4
Cancer Type: Rare Cancer

A RANDOMIZED TRIAL OF SELUMETINIB AND OLAPARIB
OR SELUMETINIB ALONE IN PATIENTS WITH RECURRENT OR
PERSISTENT RAS PATHWAY MUTANT OVARIAN AND ENDOMETRIAL
CANCERS

Protocol EAY191 - S3
Cancer Type: Rare Cancer

Phase 2 Study of Paclitaxel + Ipatasertib in Taxane-Refractory
Participants with AKT-Altered Advanced Non-Breast Solid Tumors

Please check out the rare protocol list to locate other studies within this disease site.

Sarcoma

Protocol COG AOST2031
Cancer Type: Osteosarcoma
Fast Facts

COG AOST2031

A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients with Osteosarcoma

Patients must be < 50 years at the time of enrollment

Please check out the rare protocol list to locate other studies within this disease site.

Skin

Protocol ECOG EA6141
Cancer Type: Melanoma-unresectable
Fast Facts

Randomized Phase II/III Study of Nivolumab Plus Ipilimumab Plus Sargramostim Versus Nivolumab Plus Ipilimumab in Patients With Unresectable Stage III or Stage IV Melanoma

Protocol EA6192
Cancer Type: Advanced Melanoma
Fast Facts

A Phase II Study of Biomarker Driven Early Discontinuation of anti-PD-1 Therapy in Patients with Advanced Melanoma (PET-Stop)

Protocol SWOG S2015
Cancer Type: primary cutaneous melanoma
Fast Facts

Melanoma Margins Trial (MelMarT-II): A Phase III, multi-centre, multi-national randomised control trial investigating 1cm v 2cm wide excision margins for primary cutaneous melanoma

Protocol SWOG S2101
Cancer Type: melanoma
Fast Facts

S2101: Biomarker Stratified CaboZantinib (NSC#761968) and NivOlumab (NSC#748726) (BiCaZO) - A Phase II Study of Combining Cabozantinib and Nivolumab in Participants with Advanced Solid Tumors (IO Refractory Melanoma or HNSCC) Stratified by Tumor Biomarkers - an immunoMATCH Pilot Study.

Protocol Alliance A091903
Cancer Type: RESECTED MUCOSAL MELANOMA
Fast Facts

A RANDOMIZED PHASE II TRIAL OF ADJUVANT NIVOLUMAB WITH OR WITHOUT CABOZANTINIB IN PATIENTS WITH RESECTED MUCOSAL MELANOMA

Please check out the rare protocol list to locate other studies within this disease site.

Please check out the rare protocol list to locate other studies within this disease site.

Cancer clinical trials are research studies for developing better ways of detecting, treating, and eventually preventing cancer. By taking part in a clinical trial, you are among the first to receive new research treatments before they are widely available. Your participation in a clinical trial will influence the future direction of cancer care.

If you are interested in participating in a clinical trial, consult with your physician. Please note: clinical trials are not risk free. Patients must explore the options that are best for their individuals needs with the help of their physician.