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Cancer Research Consortium of West Michigan

Adult Radiation Clinical Trials

Cancer clinical trials are research studies for developing better ways of detecting, treating, and eventually preventing cancer. By taking part in a clinical trial, you are among the first to receive new research treatments before they are widely available. Your participation in a clinical trial will influence the future direction of cancer care.

If you are interested in participating in a clinical trial, consult with your physician. Please note: clinical trials are not risk free. Patients must explore the options that are best for their individuals needs with the help of their physician.

Provided drugs are underlined

For more information, call the CRCWM Main office at 616.391.1230 or 800.336.5079

Brain/CNS

Cancer Type: Brain Metastases
Research Base: NRG
Protocol: NRG CC001

NRG CC001: A Randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy with or Without Hippocampal Avoidance in Patients with Brain Metastases. 

Clinical Summary:

Breast

Cancer Type: Triple-Negative Invasive Breast Cancer
Research Base: NRG
Protocol: NRG BR003

NRG BR003: A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer

Clinical Summary:

Cancer Type: RT for (+)Node?Neo Chemo f/b surg?(-)Node
Research Base: NRG
Protocol: NSABP B-51

NSABP B-51: A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy. 

Clinical Summary:

Cancer Type: HER2 Positive Breast Cancer w/Brain Mets
Research Base: NRG
Protocol: RTOG 1119

RTOG 1119: Phase II Randomized Study. WBRT +/- Lapatinib in patients with brain metastasis from HER2-Positive breast cancer. Stage IV.

Clinical Summary:

Cancer Control

Cancer Type: SCLC
Research Base: NRG
Protocol: NRG CC003

NRG CC003: Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung Cancer

Clinical Summary:

Cancer Type: Brain Metastases
Research Base: NRG
Protocol: NRG CC001

NRG CC001: A Randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy with or Without Hippocampal Avoidance in Patients with Brain Metastases. 

Clinical Summary:

Gastrointestinal

Cancer Type: Pancreas Adenocarcinoma Resected
Research Base: NRG
Protocol: RTOG 0848
RTOG 0848: A Phase II-R and A Phase III Trial Evaluating Both *Erlotinib (Ph II-R) and Chemoradiation (Ph III) as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma. 

Clinical Summary:

Genitourinary

Cancer Type: Prostate Cancer
Research Base: NRG
Protocol: RTOG 0924

RTOG 0924: Phase III Randomized Trial. RT (+/- whole pelvis) plus androgen deprivation therapy (short term therapy vs. long term therapy) in unfavorable intermediate or favorable high risk prostate cancer:  

Clinical Summary:

Gynecologic

Cancer Type: Cervical Carcinoma
Research Base: NRG
Protocol: RTOG 0724
 

RTOG 0724: Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy With or Without Adjuvant Chemotherapy in High-Risk Patients with Early-stage Cervical Carcinoma Following Radical Hysterectomy - 

Clinical Summary:

Cancer Type: Advanced Cervical Cancer
Research Base: NRG
Protocol: GOG 0274

GOG 0274: A Phase III trial. FIGO 2008 Stage 1B1, 1BG2, II, IIIB or IV (Stage IIIA are ineligible). Cisplatin/XRT vs Cisplatin/XRT + Additional Chemo with Carboplatin/Paclitaxel. Locally advanced cervical cancer.

Clinical Summary:

Cancer Type: GYN-newly diagnosed, bulky stage
Research Base: NRG
Protocol: NRG GY006

NRG GY006: A Randomized Phase II Trial of Radiation Therapy and Cisplatin Alone or in Combination with Intravenous Triapine in Women with Newly Diagnosed Bulky Stage IB2, Stage II, IIIB, or IVA Cancer of the Uterine Cervix or Stage II-IVA Vaginal Cancer. 

Clinical Summary:

Cancer Type: Ovarian, Fallopian Tube and Primary Peritoneal
Research Base: NRG
Protocol: NRG GY003

NRG GY003: Phase II, Nivolumab with or without Ipilimumab in Patients with Persistent or Recurrent Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancer. 

Clinical Summary:

Head and Neck

Cancer Type: Head and Neck
Research Base: ECOG-ACRIN
Protocol: EA3132

EA3132: Phase II Randomized Trial of Adjuvant Radiotherapy with or Without Cisplatin for p53 Mutated, Surgically Resected Squamous Cell Carcinoma of the Head and Neck

Clinical Summary:

Cancer Type: Head and Neck
Research Base: NRG
Protocol: RTOG 0920
 

RTOG 0920: A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer - 

Clinical Summary:

Lung

Cancer Type: SCLC
Research Base: NRG
Protocol: NRG CC003

NRG CC003: Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung Cancer

Clinical Summary: